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Bioinformatical Analysis of HGPRT Transferase from Different Malaria Parasite Plasmodium spp. Using Computational Tools

Malaysian Journal of Medical and Biological Research

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Title Bioinformatical Analysis of HGPRT Transferase from Different Malaria Parasite Plasmodium spp. Using Computational Tools
 
Creator Ali, Nahla Osman Mohamed
 
Subject HGPRT – Phosphoribosyltransferase - Plasmodium spp. - Bioinformatics – Secondary structure
 
Description In this study, HGPRT transferases from different malaria parasite Plasmodium species was analyzed and presented in this communication. The composition of leucine, lysine and Isoleucine were the highest while lowest concentrations of tryptophan and glutamine residues were noticed when compared to other amino acids. pI value of P. reichenowi HGPRT was 7.59 while the lowest pI of 6.22 was shown by P. chabaudi HGPRT. The instability index of all the transferases is varied, but for all of them it was less than 40, which indicates that all of them are stable. The aliphatic index was found to span within a range of 83 to 97. Secondary structural analysis of the transferases showed the pre-dominance of random coils followed by extended strands for all the transferases except P. falciparum, P. Knowlesi and P. reichenowi HGPRT transferase. The significance of the above results is discussed in the light of existing literature. Handle: http://hdl.handle.net/20.500.11903/mjmbr.v2n3.12 
 
Publisher i-Proclaim
 
Contributor
 
Date 2015-12-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://i-proclaim.my/archive/index.php/mjmbr/article/view/25
 
Source Malaysian Journal of Medical and Biological Research; Vol 2, No 3 (2015): 6th Issue; 242-246
2313-0016
2313-0008
 
Language eng
 
Relation http://i-proclaim.my/archive/index.php/mjmbr/article/view/25/25
 
Rights Copyright (c) 2016 Nahla Osman Mohamed Ali
http://creativecommons.org/licenses/by-nc/4.0